Monoclonal gammopathy of Audio Video Connector undetermined significance (MGUS) is the requisite precursor to multiple myeloma (MM), a malignancy of antibody-producing plasma B-cells.The genetic basis of MGUS and its progression to MM remains poorly understood.C57BL/KaLwRij (KaLwRij) is a spontaneously-derived inbred mouse strain with a high freque
Limitations of Antibiotic MIC-Based PK-PD Metrics: Looking Back to Move Forward
Within a few years after the first successful clinical use of penicillin, investigations were conducted in animal infection models to explore a range of factors that were considered likely to influence the antibacterial response to the drug.Those studies identified that the response was influenced by not only the total daily dose but also the inter
Idiosyncratic Drug-Induced Liver Injury: From Pathogenesis to Risk Reduction
Idiosyncratic drug-induced liver injury (iDILI) is a rare and poorly predictable adverse drug reaction that may lead to death or liver transplantation in severe cases.The aim of the study was to Defrost Element Kit review contemporary concepts of the immune-mediated pathogenesis of iDILI and possible ways to predict and prevent the risk of developi
A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice
We have recently shown that chemotherapy with immunogenic cell death (ICD)-inducing agents can be advantageously combined with fasting regimens or caloric restriction mimetics (CRMs) to achieve superior tumor growth control via a T cell-dependent mechanism.Here, we show that the blockade of the CD11b-dependent extravasation of myeloid cells blocks